FIG 1.

Illustration of the end points that partition the area under the overall survival curve into treatment-free survival (TFS) and other resulting health states. (*) Time after cessation of immuno-oncology (IO) protocol therapy without toxicity before initiation of subsequent systemic anticancer therapy or death. (†) Time after cessation of IO protocol therapy with toxicity while treatment free. (‡) Includes toxicity that persisted since protocol therapy and toxicity that newly presented after protocol therapy cessation.