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ERAP1-mediated trimming of HLA-B*0801E76C-bound peptides. MHC I–bound 14-mer (RA)3AAKKKYCL (A) and 20-mer (RA)6AAKKKYCL (∼12 μg of peptide) (B) were incubated with ∼34 μg of ERAP1 at 37 °C. Aliquots were taken from the mixtures at the indicated times and analyzed by MS. Additional ERAP1 was added to the mixtures after the aliquots of 3.5 and 6 h. The starting MHC I–bound peptides and fragments are indicated.
