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. 2019 Oct 22;294(49):18600–18612. doi: 10.1074/jbc.RA119.010997

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© 2019 Murphy et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 10. — A model of HIV-1 MA trimer bound to membrane. Shown are top and bottom views of the MA trimer bound to a membrane bilayer. The interaction is mediated by the myr group, the acidic polar head of PI(4,5)P₂, and basic residues (Arg²², Lys²⁶, Lys²⁷, Lys³⁰, and Lys³²) in the HBR (blue). Residues colored in red are located in the trimeric interface, as revealed by the HDX-MS data. Membrane bilayer was generated in the VMD membrane builder plug-in (92). PI(4,5)P₂ was generated in Avogadro (93). The MA trimer was constructed by superimposition of the structure of myr-exposed MA and the X-ray structure of myr(−)MA.