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Chemical and chemoenzymatic methodologies for GPA diversifications. A, chemical synthesis of oritavancin (6) and telavancin (7) from naturally-biosynthesized GPAs chloroeremomycin and vancomycin. B, combinatorial syntheses from the vancomycin aglycone: glyco-randomization at the d-glucose moiety through GftE-mediated incorporation of modified sugars and Click chemistry on a 6-azido-α-d-glucose moiety introduced by the actions of GftE.
