Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
β-Glucuronidase enzymes reactivate estrogens. Gut microbial β-glucuronidase enzymes within the GI deconjugate estrone-3- and estradiol-17-glucuronides to the aglycones estrone and estradiol, respectively. This reactivation allows unbound estrogens to be recirculated through the bloodstream, possibly contributing to a variety of hormonal disorders, including breast cancer and endometriosis.
