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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Exp Neurol. 2019 Oct 31;323:113088. doi: 10.1016/j.expneurol.2019.113088

Figure 2. MCAO-induced SVZ proliferation and neurogenesis is increased even more in female, but not male, VTN−/− mice.

Figure 2.

Female and male VTN+/+ and VTN−/− mice received a 30 min MCAO and analyzed at 14 d, with BrdU given over the last 3 days. Representative images of BrdU+ nuclei in the SVZ show that, compared to sham-operated females (A), MCAO causes an increase in VTN+/+ females (B) and even more so in VTN−/− females (C). In males, the increase compared to shams (D) was similar in VTN+/+ (E) and VTN−/− (F). Arrows indicate the SVZ. F, female, M, male, CC, corpus callosum, LV = lateral ventricle, STR, striatum, scale bar = 100 μm. Immunostaining for BrdU and the neuroblast marker, DCX, confirmed that the increased proliferation led to formation of new neuroblasts, i.e., neurogenesis in females (G-I) and males (J-L) mice. Scale bar = 50 μm.