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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Exp Neurol. 2019 Oct 31;323:113088. doi: 10.1016/j.expneurol.2019.113088

Figure 9. Astrocytic FAK deletion blocks MCAO-induced neurogenesis in the SVZ of females.

Figure 9.

Female FAK-lox control and GFAP-cre/FAK-lox mice received 5 days of tamoxifen treatment followed by MCAO 14 d later. BrdU was given during the last 50 h prior to tissue collection at 14 d following MCAO. The numbers of BrdU+ nuclei in the SVZ were counted using unbiased stereology and calculated as percent of sham-operated FAK-lox controls. MCAO caused the expected increase in BrdU+ nuclei in FAK-lox mice, but not GFAP-cre/FAK-lox mice, suggesting that selective deletion of FAK in the astrocytes blocks MCAO-induced SVZ neurogenesis. N = 6, 5, 5 and 4 mice. * p<0.05 (Two-way ANOVA followed by post hoc Tukey multiple comparisons).