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. 2019 Dec 9;10(12):940. doi: 10.1038/s41419-019-2134-8

Fig. 1. Intra-mitochondrial Src kinase is more active in triple negative breast cancer cells.

Fig. 1

a Representative immunoblottings (n = 4–6) of Src, the cytosolic protein tubulin and the mitochondrial protein succinate dehydrogenase a (SDHa) in different subcellular fractions derived from various breast cancer subtypes, showing that intra-mitochondrial Src kinase is present in most breast cancer and control cells. TCL: total cell lysate; Cyto: cytosolic fraction; Mito: mitochondrial fractions. b Representative immunoblottings (n = 4–6) of pY419-Src, total Src and tubulin in total cell lysate (TCL) obtained from breast cancer cell lines (see also Supplementary Fig. 1a, b for quantification); c Representative immunoblottings (n = 4–6) of pY419-Src, total Src and SDHa in mitochondrial-enriched fractions obtained from breast cancer cell lines, showing that mtSrc is more active in triple negative (TN) breast cancer cells (see also Supplementary Fig. 1a, b for quantification).