Table 2.
Descriptive statistics of primary and secondary outcomes by treatment condition overall and by sequence of treatment assignment
| Overall | NTX followed by MEM + NTX | MEM + NTX followed by NTX | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Outcome | Baseline (n = 56) | NTX (n = 46) | NTX + MEM (n = 47) | Baseline (n = 30) | NTX (n = 27) | NTX + MEM (n = 25) | Baseline (n = 26) | NTX (n = 19) | NTX + MEM (n = 22) |
| Total drinks consumed | 6.77 (3.99) | 5.02 (4.32)*** | 4.11 (4.19)*** | 7.57 (4.00) | 6.22 (4.32)* | 4.28 (4.37)*** | 5.85 (3.84) | 3.32 (3.80)** | 3.91 (4.06)* |
| Craving: priming | 7.03 (0.56) | 6.84 (0.57)** | 6.81 (0.55)** | 7.02 (0.60) | 6.87 (0.60)* | 6.79 (0.60)** | 7.05 (0.52) | 6.78 (0.53) | 6.84 (0.49) |
| Craving: adlib | 7.95 (0.56) | 7.75 (0.55)** | 7.62 (0.54)*** | 7.93 (0.60) | 7.81 (0.57)** | 7.57 (0.58)*** | 7.97 (0.52) | 7.67 (0.54)** | 7.68 (0.50)** |
| Stimulation: priming | 4.45 (2.36) | 3.43 (2.71)*** | 3.20 (2.84)*** | 4.35 (2.38) | 3.88 (2.53) | 3.15 (2.76)* | 4.57 (2.38) | 2.79 (2.91)** | 3.25 (2.99)** |
| Stimulation: adlib | 6.35 (2.68) | 4.93 (3.45)** | 4.78 (3.51)** | 6.30 (2.73) | 5.57 (3.24) | 4.74 (3.50)* | 6.41 (2.68) | 4.02 (3.63)*** | 4.83 (3.60)* |
| Sedation: priming | 4.15 (2.31) | 3.76 (2.34) | 3.87 (2.49) | 3.91 (2.49) | 3.55 (2.51) | 3.96 (2.38) | 4.42 (2.10) | 4.06 (2.09) | 3.78 (2.64) |
| Sedation: adlib | 5.88 (2.51) | 5.34 (3.08) | 5.42 (2.97) | 5.95 (2.51) | 5.13 (3.33) | 5.47 (3.06) | 5.79 (2.56) | 5.63 (2.76) | 5.37 (2.94) |
Values represent mean (SD); asterisks indicate significantly different from baseline, *p < 0.05, **p < 0.01, ***p < 0.001; AUQ Craving and BAES stimulation and sedation are log-transformed and represent the area under the curve (AUC) during the priming dose phase or adlib drinking phase as indicated