Table 3.
Summary of gene-based analysis using SNP-smoking interactions (at FDR < 0.05) located in genic regions for LS and non-LS, respectively.
| Chr | Gene | Start | Stop | Pvalue | Best-SNP | AP-pvalue | |
|---|---|---|---|---|---|---|---|
| LS | 1 | FCRL1 | 157764192 | 157789940 | 1.33E-03 | rs12132140 | 1.28E-03 |
| 1 | KIF14 | 200520624 | 200587966 | 2.01E-03 | rs115265657 | 1.90E-03 | |
| 5 | MAST4 | 65892175 | 66282351 | 3.88E-03 | rs17281154 | 3.80E-03 | |
| 5 | ATG10 | 81267843 | 81551213 | 2.27E-02 | rs17245874 | 2.21E-02 | |
| 5 | TNIP1 | 150409503 | 150444692 | 7.04E-03 | rs3805431 | 6.93E-03 | |
| 5 | SLIT3 | 168088737 | 168728133 | 1.09E-02 | rs6890724 | 1.03E-02 | |
| 6 | FARS2 | 5261250 | 5771825 | 5.72E-03 | rs17140294 | 6.08E-03 | |
| 6 | RREB1 | 7107829 | 7252213 | 2.05E-02 | rs482393 | 2.03E-02 | |
| 8 | PINX1 | 10622470 | 10697409 | 8.76E-03 | rs17152442 | 8.16E-03 | |
| 8 | ADHFE1 | 67344717 | 67381044 | 1.93E-03 | rs1060242 | 1.96E-03 | |
| 12 | VWF | 6058039 | 6233841 | 3.40E-03 | rs3759321 | 3.49E-03 | |
| 12 | CLIP1 | 122755980 | 122907116 | 2.47E-02 | rs11057405 | 2.47E-02 | |
| 13 | MYCBP2 | 77618791 | 77901177 | 5.54E-03 | rs34700794 | 5.48E-03 | |
| 17 | CLEC10A | 6977855 | 6983626 | 2.02E-02 | rs11653290 | 2.03E-02 | |
| 17 | CCR7 | 38710020 | 38716646 | 2.48E-02 | rs2290065 | 2.49E-02 | |
| 19 | NLRP7 | 55434876 | 55458873 | 5.89E-03 | rs73055288 | 5.33E-03 | |
| non-LS | 1 | IL23R | 67632168 | 67725662 | 4.59E-04 | rs61780312 | 3.00E-04 |
| 1 | RPL31P11 | 161653484 | 161655042 | 1.09E-02 | rs114384494 | 1.04E-02 | |
| 2 | ANKRD44 | 197851385 | 198175521 | 1.79E-02 | rs35272229 | 1.77E-02 | |
| 5 | AGXT2 | 34998205 | 35048240 | 8.80E-03 | rs17245714 | 8.93E-03 | |
| 5 | ZNF300P1 | 150309997 | 150326146 | 3.14E-03 | rs17658318 | 3.47E-03 | |
| 6 | BACH2 | 90636246 | 91006627 | 2.31E-03 | rs57858238 | 2.79E-03 | |
| 11 | CD6 | 60739112 | 60787849 | 5.10E-04 | rs79460410 | 5.19E-04 | |
| 11 | PHRF1 | 576445 | 612222 | 7.32E-03 | rs118042921 | 7.76E-03 | |
| 11 | CYB5R2 | 7686325 | 7695474 | 5.13E-03 | rs61729556 | 5.31E-03 | |
| 14 | NUMB | 73741917 | 73925286 | 6.71E-03 | rs177372 | 6.84E-03 | |
| 16 | HSD11B2 | 67465035 | 67471456 | 4.82E-03 | rs5479 | 5.32E-03 | |
| 16 | FAM65A | 67562719 | 67580691 | 1.95E-03 | rs75204333 | 2.09E-03 | |
| 18 | BCL2 | 60790578 | 60986613 | 1.47E-02 | rs4987801 | 1.50E-02 |