Mean food intake (±SEM) across the 12 days of IVSA in male, female, and OVX female rats. The top panels (a–c) reflect daily responses and the bottom panel reflects mean intake (d). The asterisk (*) denotes a significant difference between Nicotine-CRF and Nicotine-GFP groups, the number sign (#) denotes a difference from the respective male group, the dagger (†) denotes a difference from the respective OVX female group, and the at sign (@) denotes a difference between Saline-CRF versus Nicotine-CRF rats (p ≤ 0.05)