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. 2019 Dec 3;10:2712. doi: 10.3389/fmicb.2019.02712

FIGURE 2.

FIGURE 2

Scheme for proteins used as candidates for an antimalarial vaccine (I). Color code: blue, whole protein; yellow, functional domain; orange, N-terminal signal peptide; green, conserved high-activity binding peptides (cHABPs) with Fundación Instituto de Inmunología de Colombia (FIDIC)-assigned coding; purple, cytoplasmic domain. (A) MSP3-LSP vaccine, including B1, B2, and B3 domains (yellow). (B) P27A vaccine, including ring domain (yellow). (C) BK-SE36 vaccine. (D) AMA-1-DiCo vaccine, including domain I (purple), domain II (red), variable amino acids (pink), and cHABPs 4325 (green) and 4313 (magenta). PDB 4R19 (Lim et al., 2014). (E) PAMVAC and PRIMVAC vaccines. Top: Protein scheme, CIDRα1 (cysteine-rich inter-domain regions α1), C2 (C2 domain), and Duffy binding-like (DBL) domain. Bottom: Protein structure, including the NTS region (blue), whole protein (green), and cHABPs 6510 (purple) and 6512 (orange). PDB 2XU0.