Table 1.
Summary of peri-implant tissue response with respective scores for each implant, osseointegrated in proof of concept trial in animal models.
| Period of observation | Test Implants | Score | Control Implants | Score | Observation/Findings |
|---|---|---|---|---|---|
| 2 weeks (Rabbit No. 1) | Implant no. 1 | — | Implant no. 1 | — | — |
| Implant no. 2 | — | Implant no. 2 | — | — | |
| 4 weeks (Rabbit No. 2) | Implant no. 1 | 0 | Implant no. 1 | 0 | Unremarkable morphology |
| Implant no. 2 | 0 | Implant no. 2 | 2 | Moderate hyperplastic mass on peri-implant area of control implant (no. 2) | |
| 6 weeks (Rabbit No. 3) | Implant no. 1 | 0 | Implant no. 1 | 1 | Slight hyperplastic mass on peri-implant area of control implant (no. 1) |
| Implant no. 2 | 1 | Implant no. 2 | 0 | Slight hyperplastic mass on peri-implant area of test implant (no. 2) | |
| 8 weeks (Rabbit No. 4) | Implant no. 1 | 0 | Implant no. 1 | 0 | Unremarkable morphology |
| Implant no. 2 | 0 | Implant no. 2 | 2 | Moderate hyperplastic mass on peri-implant area of control implant (no. 2) | |
| 12 weeks (Rabbit No. 5) | Implant no. 1 | 0 | Implant no. 1 | 0 | Unremarkable morphology |
| Implant no. 2 | 0 | Implant no. 2 | 1 | Slight hyperplastic mass on peri-implant area of control implant (no. 2) | |
| 12 weeks (Rabbit No. 6) | Implant no. 1 | 0 | Implant no. 1 | 1 | Slight hyperplastic mass on peri-implant area of control implant (no. 1) |
| Implant no. 2 | 0 | Implant no. 2 | 1 | Slight hyperplastic mass on peri-implant area of control implant (no. 2) |