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. 2019 Dec 9;10:5622. doi: 10.1038/s41467-019-13515-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — LMO1 co-occupies targets with the members of the ADRN CRC. a The LMO1-bound nonpromoter loci were first identified in Kelly cells. Density plots show the distribution of LMO1, GATA3, MYCN, PHOX2B, HAND2, TBX2 and ISL1, H3K27ac and H3K4me1 signals at the LMO1-bound regions (±3 kb from binding sites) in Kelly and LMO1, GATA3, H3K27ac and H3K4me1 signals at the same regions in Jurkat cells. The color scale shows the intensity of the distribution signal. b Metagene plots show distribution of LMO1, GATA3, MYCN, H3K27ac, and H3K4me1 signals at the LMO1-bound regions (±3 kb from binding sites) in Kelly and Jurkat cells. c Metagene plots show distribution of H3K27ac signals at the LMO1-bound regions (±5 kb from binding sites) in various neuroblastoma cell lines. Cell lines were classified based on the expression level of LMO1 mRNA.