Table 2.

Meta-analysis of published literature, addressing mortality trends in osteoarthritis patients.

#	PMID	N	HR	#	PMID	N	HR
Meta-analysis of published literature
1	30169829[d]	5.2 × 104	1.3/1, K-RKOA	18	20416065	2163	0.92 HRE
2	29588472*[sec]	809	0.76/1.1 HRE/KRE	19	17540743	6.4 × 104	0.77 HRE, KRE < 12 years follow up
3	28754502	601	1.97 K	20	12784389	2.35 × 106	1.0 OA
4	28607349[w]	1025	1.98 K	21	12525385	7200	1.1 H
5	27866950	4278	0.86 KRE/HRE	22	10743987	3.9 × 104	0.73 HRE
6	26543059	821 (K), 806(H)	2.0, 1.0 K/H	23	28375889*	7.1 × 105	0.6 HRE/KRE
7	26986874[d]	5.2 × 105	0.9 K, HP	24	29489471*	1.3 × 105	0.98 HRE
8	17462546[ed]	7.4 × 105	0.72	25	26704362	5853	0.9 SAR
9	26777550*	3625	0.81 KRE/HRE	26	29158649	358	0.91 KRE
10	26751980*	9443	0.73 (K, <10 years follow up), 1.9 (>20 years follow up)	27	26871792*	3.6 × 105	0.84 (at 5 years follow up), 1.1 (>10 years follow up)
11	24047870	1348	1.0 H	28	28754502	601	1.97 K
12	25778744	7889	1.14 HP	29	25179456	850	0.5 OA
13	25819581	1025	1.6 K	30	21385807	1163	1.55 OA
14	24608134	2125	1.27 K	31	21282754	1.7 × 105	0.7 HRE
15	15252092	8000	1.32 H	32	24158755	1290	1.4 OA
16	doi: 10.1093/rheumatology/kez108.062	8066	1.18 H, K	33	30583096	4182	1.15 K
17	30559011*	4907	0.95 HRE 1.45 HRE	34	30302017*	1.3 × 106	0.65 (3 years) 0.85 (7 years), HRE, KRE

Meta-analysis of literature includes PubMed ID number of the source (PMID), the size of the study (N), the average hazard ratio in sub-cohorts (HR) for all-cause mortality in OA, K – knee generic, RKOA – knee radiographic, KSR – knee self-reported, H - hand generic, HP – hip generic, HRE – hip replacement, KRE- knee replacement, OA – osteoarthritis generic, SAR – shoulder arthroplastic, SEC – secondary, P – primary.

*The publications describing initial decrease of all-cause mortality followed by subsequent increase; [w] The publications describing the effect of decreased mobility associated with knee OA on all-cause mortality, [ed] Mutual exclusion of diseases, [d] Reductions in selected co-morbidities vs. control.