Fig. 1.

Young mice successfully perform memory updating in the OUL task. a Experimental design. b Training session behavior. Mice show a low DI, indicating no preference for object A₁ or A₂ (left) and have similar levels of total object exploration (right). c Update session behavior. (i) Mice in the Update condition prefer the novel location A₃ to the familiar location A₁ whereas No Update mice show similar exploration of the familiar locations A₁ and A₂, with a DI near zero. (ii) Update mice show significantly more total object exploration than No Update mice. d Behavior during the test session. (i) Mice in both the Update and No Update group show intact memory for the original training object location A₁. (ii) Both groups also show memory for original training location A₂. (iii) Only the Update group shows a preference for the novel location A₄ over the updated location A₃; No Update mice prefer objects A₃ and A₄ equally. (iv) Mice show similar levels of total object exploration during the test session. Data are presented as mean ± SEM. **p < 0.01