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. 2019 Dec 9;9:18635. doi: 10.1038/s41598-019-54566-4

Table 2.

Secreted factors unique in bone-conditioned media.

Protein Accession Gene
Name
Protein Description MW
[kDa]
Protein
Score
#
Signif. Matches
#
Unique Peptides
Sequence Coverage Bone-CM1* Bone-CM2*
Growth Factors
[FETUA_MOUSE] Ahsg Alpha-2-HS-glycoprotein OS = Mus musculus GN = Ahsg PE = 1 SV = 1 37.3 252.56 7 4 15.94 yes
[DKK3_MOUSE] Dkk3 Dickkopf-related protein 3 OS = Mus musculus GN = Dkk3 PE = 2 SV = 1 38.4 136.07 2 2 10.60 yes
[NGAL_MOUSE] Lcn2 Neutrophil gelatinase-associated lipocalin OS = Mus musculus GN = Lcn2 PE = 1 SV = 1 22.9 128.01 4 3 16.50 yes
[NPTX1_MOUSE] Nptx1 Neuronal pentraxin-1 OS = Mus musculus GN = Nptx1 PE = 2 SV = 1 47.1 68.33 1 1 5.09 yes
[VASN_MOUSE] Vasn Vasorin OS = Mus musculus GN = Vasn PE = 2 SV = 2 72.2 65.32 2 2 7.88 yes
[MIA_MOUSE] Mia Melanoma-derived growth regulatory protein OS = Mus musculus GN = Mia PE = 2 SV = 2 14.6 34.91 1 1 6.92 yes yes
[NEO1_MOUSE] Neo1 Neogenin OS = Mus musculus GN = Neo1 PE = 1 SV = 1 163.1 31.17 1 1 1.21 yes
[LECT1_MOUSE] Lect1 Leukocyte cell-derived chemotaxin 1 OS = Mus musculus GN = Lect1 PE = 1 SV = 2 37.2 26.23 1 1 2.10 yes
Others
[NUCB1_MOUSE] Nucb1 Nucleobindin-1 OS = Mus musculus GN = Nucb1 PE = 1 SV = 2 53.4 506.84 12 9 24.84 yes yes
[CALU_MOUSE] Calu Calumenin OS = Mus musculus GN = Calu PE = 1 SV = 1 37.0 337.55 7 6 31.75 yes yes
[CH3L1_MOUSE] Chi3l1 Chitinase-3-like protein 1 OS = Mus musculus GN = Chi3l1 PE = 1 SV = 3 43.9 327.84 11 6 21.08 yes
[PPBT_MOUSE] Alpl Alkaline phosphatase OS = Mus musculus GN = Alpl PE = 1 SV = 2 57.5 299.32 6 5 15.27 yes yes
[CLUS_MOUSE] Clu Clusterin OS = Mus musculus GN = Clu PE = 1 SV = 1 51.6 193.06 5 4 10.94 yes
[OLFL3_MOUSE] Olfml3 Olfactomedin-like protein 3 OS = Mus musculus GN = Olfml3 PE = 2 SV = 2 45.7 158.37 3 3 7.88 yes yes
[NGP_MOUSE] Ngp Neutrophilic granule protein OS = Mus musculus GN = Ngp PE = 1 SV = 1 19.3 83.71 1 1 12.57 yes
[UCMA_MOUSE] Ucma Unique cartilage matrix-associated protein OS = Mus musculus GN = Ucma PE = 1 SV = 1 16.6 76.49 1 1 9.42 yes yes
[SAP_MOUSE] Psap Prosaposin OS = Mus musculus GN = Psap PE = 1 SV = 2 61.4 69.91 3 1 3.59 yes yes
[CCD80_MOUSE] Ccdc80 Coiled-coil domain-containing protein 80 OS = Mus musculus GN = Ccdc80 PE = 1 SV = 2 107.5 60.21 1 1 1.26 yes
[DAG1_MOUSE] Dag1 Dystroglycan OS = Mus musculus GN = Dag1 PE = 1 SV = 4 96.8 57.62 1 1 1.79 yes
[CRTAP_MOUSE] Crtap Cartilage-associated protein OS = Mus musculus GN = Crtap PE = 1 SV = 3 46.1 51.66 1 1 2.75 yes
[CDSN_MOUSE] Cdsn Corneodesmosin OS = Mus musculus GN = Cdsn PE = 2 SV = 2 54.3 36.81 1 1 3.21 yes

*Identified in bone-conditioned media Bone-CM1, Bone-CM2, or both as indicated.