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. 2019 Dec 9;9:18614. doi: 10.1038/s41598-019-55156-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutational patterns in panNETs ≤2 cm and >2 cm. (A) The number of mutations identified in panNETs >2 cm is significantly higher than in smaller tumors. In particular, panNETs >2 cm in diameter are enriched in mutations of DAXX. The overall rate of mutations of MEN1, DAXX and TSC2 was 21.4%, 14.3% and 12.5% respectively. The asterisk marks statistical significance as defined by p ≤ 0.05. (B) The driver plot displays the somatic mutations identified in panNETs ≤2 cm (n = 27) and > 2 cm (n = 29). Of the 19 genes sequenced, 3 genes (MLL3, DIS3L2, URGCP) were always wild-type, and therefore are not represented in the plot.

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