Table 2.
Association between CASP7 polymorphisms and risk of IS.
| Polymorphisms | Controls, n = 652 (%) | IS, n = 505 (%) | Adjusted OR (95% CI)† | P value |
|---|---|---|---|---|
| rs12415607 | ||||
| CC | 219 (33.6) | 215 (42.6) | 1.00 | |
| CA | 300 (46.0) | 223 (44.2) | 0.76 (0.58–1.00) | 0.05 |
| AA | 133 (20.4) | 67 (13.3) | 0.55 (0.38–0.80) | 0.002 |
| Dominant model | 433 (66.4) | 290 (57.4) | 0.70 (0.54–0.91) | 0.007 |
| Recessive model | 519 (79.6) | 438 (86.7) | 0.64 (0.46–0.90) | 0.01 |
| C allele | 738 (56.6) | 653 (64.7) | 1.00 | |
| A allele | 566 (43.4) | 357 (35.3) | 0.74 (0.62–0.89) | 0.001 |
| rs2227310 | ||||
| CC | 216 (33.1) | 191 (37.8) | 1.00 | |
| CG | 334 (51.2) | 243 (48.1) | 0.84 (0.64–1.10) | 0.21 |
| GG | 102 (15.6) | 71 (14.1) | 0.85 (0.58–1.24) | 0.39 |
| Dominant model | 436 (66.9) | 314 (62.2) | 0.84 (0.65–1.10) | 0.21 |
| Recessive model | 550 (84.4) | 434 (85.9) | 0.94 (0.66–1.33) | 0.71 |
| C allele | 766 (58.7) | 625 (61.9) | 1.00 | |
| G allele | 538 (41.3) | 385 (38.1) | 0.91 (0.76–1.09) | 0.29 |
| rs10787498 | ||||
| TT | 369 (56.6) | 298 (59.0) | 1.00 | |
| TG | 253 (38.8) | 189 (37.4) | 0.89 (0.69–1.16) | 0.39 |
| GG | 30 (4.6) | 18 (3.6) | 0.74 (0.39–1.41) | 0.35 |
| Dominant model | 283 (43.4) | 207 (41.0) | 0.88 (0.68–1.13) | 0.30 |
| Recessive model | 622 (95.4) | 487 (96.4) | 0.77 (0.41–1.47) | 0.43 |
| T allele | 991 (76.0) | 785 (77.7) | 1.00 | |
| G allele | 313 (24.0) | 225 (22.3) | 0.89 (0.72–1.09) | 0.26 |
| rs1127687 | ||||
| GG | 430 (66.0) | 325 (64.4) | 1.00 | |
| AG | 198 (30.4) | 165 (32.7) | 1.11 (0.84–1.45) | 0.46 |
| AA | 24 (3.7) | 15 (3.0) | 0.73 (0.35–1.50) | 0.39 |
| Dominant model | 222 (34.0) | 180 (35.6) | 1.07 (0.82–1.38) | 0.63 |
| Recessive model | 628 (96.3) | 490 (97.0) | 0.72 (0.35–1.46) | 0.36 |
| G allele | 1058 (81.1) | 815 (80.7) | 1.00 | |
| A allele | 246 (18.9) | 195 (19.3) | 1.01 (0.81–1.27) | 0.91 |
| rs4353229 | ||||
| TT | 205 (31.4) | 155 (30.7) | 1.00 | |
| CT | 320 (49.1) | 260 (51.5) | 1.11 (0.84–1.48) | 0.45 |
| CC | 127 (19.5) | 90 (17.8) | 0.92 (0.63–1.33) | 0.65 |
| Dominant model | 447 (68.6) | 350 (69.3) | 1.07 (0.81–1.40) | 0.64 |
| Recessive model | 525 (80.5) | 415 (82.2) | 0.87 (0.63–1.20) | 0.39 |
| T allele | 730 (56.0) | 570 (56.4) | 1.00 | |
| C allele | 574 (44.0) | 440 (43.6) | 0.99 (0.82–1.18) | 0.87 |
CASP7, caspase 7; IS, ischemic stroke; OR, odds ratio; CI, confidence interval.
†Adjusted by age, gender, hypertension, and diabetes mellitus.