Table 1.

Summary of RT-QuIC substrates (PrP) used to analyze different tissues of CWD affected cervid species.

Species	Prion	Tissue analyzed	Substrate	Year	References
Deer	CWD	Brain	Deer PrP (24–234)	2010	130
Deer	CWD	Brain, urine and feces	Deer PrP (24–234)	2013	80
Deer	CWD	Saliva	Syrian hamster PrP (90–231)	2013	79
Deer	CWD	Blood	Syrian hamster PrP (90–231)	2013	77
Deer	CWD	CSF	Syrian hamster PrP (90–231)	2013	71
Deer	CWD	Retropharyngeal lymph node	Syrian hamster PrP (90–231)	2014	131
Deer	CWD	Brain, saliva	Syrian hamster PrP (90–231)	2015	132
Deer Elk	CWD	Brain	Bank vole (23–230)	2015	100
Deer	CWD	Saliva, urine	Syrian hamster PrP (90–231)	2015	78
Deer	CWD	Brain	Deer PrP (23–231)	2015	124
Deer	CWD	RAMALT, nasal brush	Syrian hamster PrP (90–231)	2016	75
Elk	CWD	RAMALT, nasal brush	Syrian hamster PrP (90–231)	2016	76
Deer	CWD	Feces	Syrian hamster PrP (90–231)	2016	69
Deer	CWD	Brain, lymphoid tissues	Syrian hamster PrP (90–231)	2017	133
Deer	CWD	Ovary tissue, uterine tissue, placentome, amniotic and allantoic fluids	Syrian hamster PrP (90–231)	2017	134
Deer	CWD	Brain	Deer PrP (24–234)	2017	135
Deer	CWD	Gastrointestinal tissues (e.g. omasum, abomasum, colon, cecum) and lymphoid tissues (e.g. spleen, tonsils)	Syrian hamster PrP (90–231)	2017	136
Elk	CWD	Feces	Syrian hamster PrP (90–231)	2017	82
Elk	CWD	RAMALT	Syrian hamster PrP (90–231)	2017	137
Deer	CWD	Saliva	Syrian hamster PrP (90–231)	2017	138
Deer Elk	CWD	RAMALT	White-tailed deer PrP (25–232)	2017	139
			Mule deer PrP (25–232)
			Fallow deer PrP (25–232)
			Elk PrP (25–232)
			Reindeer PrP (25–232)
Elk	CWD	Blood, rectal biopsy	Syrian hamster PrP (90–231)	2018	140
Deer Elk	CWD	Retropharyngeal lymph node, brain	Syrian hamster PrP (90–231)	2018	60
Deer	CWD	Saliva	Syrian hamster PrP (90–231)	2018	70
Elk	CWD	Brain	Elk PrP (23–231)	2018	141
Elk	CWD	Brain	Syrian hamster PrP (90–231)	2019	4
Deer	CWD	Brain	Syrian hamster PrP (90–231)	2019	142
Deer	CWD	Brain, eyelids	Syrian hamster PrP (90–231)	2019	143