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. 2019 Dec 3;10:2757. doi: 10.3389/fimmu.2019.02757

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Copyright © 2019 Frommer, Hasseli, Schäffler, Lange, Rehart, Steinmeyer, Rickert, Sarter, Zaiss, Culmsee, Ganjam, Michels, Müller-Ladner and Neumann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human osteoclasts and their precursors from rheumatoid arthritis (RA) patients respond differently to free fatty acids than their counterparts from osteoarthritis (OA) patients. Palmitic acid and linoleic acid significantly increased the interleukin-8 (IL-8) secretion of RA osteoclasts and their precursors (n = 4), particularly at the earliest time point (d8) (A–C), while equivalent cells from OA patients (n = 4) only showed weaker effects without statistical significance (D–F). *p < 0.05; **p < 0.001; and ***p < 0.001.