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. 2019 Dec 3;10:2826. doi: 10.3389/fimmu.2019.02826

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Copyright © 2019 John, Kotze, Ribechini, Walzl, Du Plessis and Lutz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cav-1 deficient MDSCs show reduced intracellular TLR2 but not TLR4 in BCG-infected vesicles. MDSCs were stimulated with BCG-GFP for 16 h at 1 MOI. Cytospins were stained for TLR2 (A) or TLR4 (B) and analyzed by confocal microscopy. G-MDSCs and M-MDSCs were identified on the basis of polymorphonuclear or mononuclear shape by DAPI staining. All scale bars 11μm. (C,D) Quantified data of raw intensity/area for TLR2 or TLR4. of M-MDSCs from WT and Cav1^−/− mice. (E,F) Pearson's correlation coefficients for colocalization of BCG with TLR2 overlap and BCG with TLR4 overlap. Data represent for (C) n = 30 cells, for (D) n = 30 cells, and for (E,F) n = 10 cells. ****P < 0.0001; **P < 0.01; ns, not significant unpaired, two-tailed, student's t-test.