Table 1.

Cancer Related Variants Returned to Participants

Finding Participant Information
Gene	Variant	Interpretation	Cancer Diagnosis	Sex	Previous Genetic Testing	Reason for denial
BRCA2	p.Glu1285fs	Pathogenic	Gastric cancer diagnosed age 36	Female	None	E/I
BRIP1	p.Arg798*	Pathogenic	Ovarian cancer age 63	Female	None	E/I
HOXB13	p.Gly84Glu	Pathogenic	Two primary breast cancers diagnosed age 34	Female	BRCA1/2; sequencing and del/dup	NMC
PALB2	p.Thr799fs	Pathogenic	Breast cancer age 54	Female	None	E/I
CHEK2	p.Thr410fs	Pathogenic, low penetrance	Breast cancer diagnosed age 49	Female	None	NMC
ATM	p.Cys977Tyr	VUS	Breast cancer age 54	Female	None	E/I
BARD1	p.Arg751Trp	VUS	Breast cancer age 51	Female	BRCA1/2; sequencing and del/dup	NMC
BMPR1A	p.Glu468Lys	VUS	Colon cancer diagnosed age 48	Female	None	Unknown

VUS = variant of uncertain significance; E/I = experimental/investigational; NMC = patient did not meet medical criteria