Table 8.

Pharmacokinetic profile of Simoctocog Alfa (dose: 50 IU/Kg) in pediatric, adolescent, and adult PTPs with severe HA (chromogenic substrate assay) (data from product characteristics documentation).

	Patient age
Pharmacokinetic parameter	2–5 years (n = 13)	6–12 years (n = 12)	18–65 years (n = 20)
AUC (h*UI/ml)	11.7 ± 5.3	13.2 ± 3.4	22.6 ± 8.0
t 1/2 (h)	9.5 ± 3.3	10.0 ± 1.9	14.7 ± 10.4
IVR (%/UI/kg)	1.9 ± 0.3	1.9 ± 0.4	2.5 ± 0.4
Clearance (ml/h/kg)	5.4 ± 2.4	4.3 ± 1,2	3.0 ± 1.2

Values reported are mean ± SD.