Skip to main content
. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Toxicol Pathol. 2019 Jun 10;48(1):152–173. doi: 10.1177/0192623319854326

Figure 4.

Figure 4

Figure 4

Figure 4

Examples of degenerative and regenerative responses of Schwann cells and axons. (a) Schwann cell hyperplasia exhibiting an increased cytoplasmic volume, enclosed by the extension of basal lamina (arrows), that is filled with rough endoplasmic reticulum and various vesicular structures from disrupted membranous organelles. (b) A cluster of regenerating axonal sprouts that have not yet been myelinated surrounded by persistent basal lamina from previous Schwann cells and the processes of supernumerary Schwann cells (arrows). (c) A regenerated axon (A) ensheathed with thin myelin (M) from its current Schwann cell sectioned through the cell body showing the nucleus (N) and cytoplasm (C) that is surrounded by persistent basal lamina (arrows) of previous Schwann cells and the processes of supernumerary Schwann cells (arrowheads).