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. Author manuscript; available in PMC: 2021 Jan 1.

Published in final edited form as: Toxicol Pathol. 2019 Jun 10;48(1):152–173. doi: 10.1177/0192623319854326

Segmental demyelination and intramyelinic edema in the sciatic nerve of rats administered disulfiram. (a) Teased fiber from an animal exposed to disulfiram showing loss of myelin from an entire internode. An abrupt change to normal myelin thickness is seen on both sides of the demyelinated internode at each node of Ranvier. (b) A demyelinated axon (A) surrounded by a Schwann cell sectioned through the cell body showing the nucleus (N) and increased cytoplasmic volume (C) filled with vesicular structures and debris. Processes of supernumerary Schwann cells are present (arrows). (c) Several layers of the compact myelin lamella have separated and the space created is filled with fluid (intramyelinic edema). The axon (A) has a relatively normal density and distribution of mitochondria and neurofilaments but the axolemma (arrows) has separated from contact with the Schwann cell plasma membrane at the inner layers of compact myelin.

Segmental demyelination and intramyelinic edema in the sciatic nerve of rats administered disulfiram. (a) Teased fiber from an animal exposed to disulfiram showing loss of myelin from an entire internode. An abrupt change to normal myelin thickness is seen on both sides of the demyelinated internode at each node of Ranvier. (b) A demyelinated axon (A) surrounded by a Schwann cell sectioned through the cell body showing the nucleus (N) and increased cytoplasmic volume (C) filled with vesicular structures and debris. Processes of supernumerary Schwann cells are present (arrows). (c) Several layers of the compact myelin lamella have separated and the space created is filled with fluid (intramyelinic edema). The axon (A) has a relatively normal density and distribution of mitochondria and neurofilaments but the axolemma (arrows) has separated from contact with the Schwann cell plasma membrane at the inner layers of compact myelin.