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Schematic presentation of the JAK/STAT pathway and the role of JAK inhibitory drugs. Binding of cytokines to receptors, which rely on the JAK/STAT pathway for signal transduction, leads to phosphorylation of JAK and STAT proteins. The latter dimerize, translocate into the nucleus and regulate the expression of inflammatory factors. JAK inhibitors (JAKi) prevent JAK phsophorylation and STAT activation. Figure was created with the help of Biorender.com.
