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. 2019 Dec 18;12(12):1898–1907. doi: 10.18240/ijo.2019.12.13

Table 2. Clinical resolution and bacterial eradication rates of different species.

Parameters Treatments No. of patients OR 95%CI P χ2 I2 Effect model
Rates of bacterial eradication
4d
Gram-positive Besifloxacin vs placebo 755 7.33 4.18-12.85 <0.00001 0.11 50% Random effect
Besifloxacin vs moxifloxacin 368 1.26 0.63-2.55 0.51 - - Random effect
Besifloxacin vs gatifloxacin 31 9.33 1.50-58.20 0.02 - - Random effect
Gram-negative Besifloxacin vs placebo 438 4.29 2.52-7.28 <0.00001 0.92 0 Random effect
Besifloxacin vs moxifloxacin 214 1.26 0.34-4.59 0.73 - - Random effect
Besifloxacin vs gatifloxacin 10 5.57 0.18-176.26 0.33 - - Random effect
H. influenzae Besifloxacin vs placebo 281 4.01 2.19-7.32 <0.00001 0.90 0 Random effect
Besifloxacin vs moxifloxacin 169 1.16 0.30-4.48 0.83 - - Random effect
S. pneumoniae Besifloxacin vs placebo 215 2.21 1.14-4.29 0.02 0.60 0 Random effect
Besifloxacin vs moxifloxacin 122 1.02 0.37-2.85 0.97 - - Random effect
S. aureus Besifloxacin vs placebo 141 9.11 3.50-23.72 <0.00001 0.39 0 Random effect
Besifloxacin vs moxifloxacin 113 1.55 0.55-4.40 0.41 - - Random effect
Besifloxacin vs gatifloxacin 5 7.00 0.17-291.34 0.31 - - Random effect
S. epidermidis Besifloxacin vs placebo 109 4.58 1.74-12.10 0.002 0.36 3% Random effect
Besifloxacin vs moxifloxacin 63 4.8 0.55-42.23 0.16 - - Random effect
Besifloxacin vs gatifloxacin 7 7.00 0.22-218.95 0.27 - - Random effect
8d
Gram-positive Besifloxacin vs placebo 753 4.23 2.90-6.17 <0.00001 0.75 0 Random effect
Besifloxacin vs moxifloxacin 368 1.04 0.58-1.87 0.88 - - Random effect
Besifloxacin vs gatifloxacin 31 1.42 0.08-24.95 0.81 - - Random effect
Gram-negative Besifloxacin vs placebo 437 2.14 1.29-3.57 0.003 0.61 0 Random effect
Besifloxacin vs moxifloxacin 214 1.9 0.82-4.41 0.14 - - Random effect
Besifloxacin vs gatifloxacin 10 2.13 1.41-3.21 - - - Random effect
H. influenzae Besifloxacin vs placebo 369 2.36 1.31-4.23 0.004 0.34 11% Random effect
Besifloxacin vs moxifloxacin 169 1.17 0.44-3.13 0.75 - - Random effect
S. pneumoniae Besifloxacin vs placebo 215 2.21 1.14,4.29 0.02 0.6 0 Random effect
Besifloxacin vs moxifloxacin 122 1.02 0.37-2.85 0.97 - - Random effect
S. aureus Besifloxacin vs placebo 210 9.53 4.47-20.32 <0.00001 0.74 0 Random effect
Besifloxacin vs moxifloxacin 115 1.15 0.45-2.96 0.78 - - Random effect
S. epidermidis Besifloxacin vs placebo 225 9.86 3.80-25.59 <0.0001 0.25 27% Random effect
Besifloxacin vs moxifloxacin 70 2.02 0.56-7.21 0.28 - - Random effect
Besifloxacin vs gatifloxacin 7 1.67 0.05-58.28 0.78 - - Random effect
Clinical resolution
4d
Gram-positive Besifloxacin vs placebo 532 2.12 1.47-3.06 <0.0001 0.82 0 Random effect
Besifloxacin vs moxifloxacin 368 0.91 0.60-1.37 0.65 - - Random effect
Gram-negative Besifloxacin vs placebo 328 1.63 0.98-2.69 0.06 0.31 15% Random effect
Besifloxacin vs moxifloxacin 214 1.2 0.68-2.14 0.52 - - Random effect
8d
Gram-positive Besifloxacin vs placebo 532 1.97 1.34-2.90 0.0005 0.4 0 Random effect
Besifloxacin vs moxifloxacin 368 1.14 0.67-1.94 0.64 - - Random effect
Gram-negative Besifloxacin vs placebo 331 2.47 1.19-5.13 0.02 0.18 41% Random effect
Besifloxacin vs moxifloxacin 214 0.81 0.35-1.89 0.63 - - Random effect