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The flowchart demonstrates different steps for the extraction of radiomics features from T2W images and ADC maps for DILs and normal tissues. As shown in this figure, for each MR modality, 168 radiomics features are extracted from normal and DIL volumes. The optimal feature set for the two MR modalities are identified using ANOVA applied on the latent variables generated by the PLSC technique for features with Silhouette coefficient of 0.5 and greater.
