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. 2019 Nov 26;10:1535. doi: 10.3389/fpls.2019.01535

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Copyright © 2019 Bellato, De Marchi, Gualtieri, Sauta, Magni, Macovei and Pasotti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of conserved plant miRNAs potentially targeting human genes. Alignments between three conserved miRNAs (miR390, miR164, miR166) from different plant species, namely Solanum lycopersicum (sly), Malus domestica (mdm), and M. truncatula (mtr), show 100% sequence similarity. The predicted human target genes found in the enriched biological processes of the network-based approach and among the genes with significant sequence similarity in the alignment-based approach are shown in red and blue circles, respectively. Abbreviations: KIRREL3, Kirre Like Nephrin Family Adhesion Molecule 3; SIRT3, Sirtuin 3; MARCH6, Membrane Associated Ring-CH-Type Finger 6; TCOF1, Treacle Ribosome Biogenesis Factor 1; SLC7A5, Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System), Member 5; JADE2, Jade Family PHD Finger 2; LRRC41, Leucine Rich Repeat Containing 41; MICAL3, Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3; SMG6, Nonsense Mediated MRNA Decay Factor; PLXNA4, Plexin A4; AGPAT5, 1-Acylglycerol-3-Phosphate O-Acyltransferase 5; PTDSS2, Phosphatidylserine Synthase 2; CD83, Cluster of Differentiation 83; ZXDC, ZXD Family Zinc Finger C; FBXO21, F-Box Protein 21; GLT1D1, Glycosyltransferase 1 Domain Containing 1; GNAI2, G Protein Subunit Alpha I2; ZNF578, Zinc Finger Protein 578; NES, Nestin; POLR3H, RNA Polymerase III Subunit H; CDX1, Caudal Type Homeobox 1; CPN2, Carboxypeptidase N Subunit 2; DIRK1B, Dual specificity tyrosine-phosphorylation-regulated kinase 1B; MXD4, MAX Dimerization Protein 4; NSD2, Nuclear Receptor Binding SET Domain Protein 2; PRDM16, Histone-lysine N-methyltransferase PR/SET Domain 16; SCUBE1, Signal Peptide, CUB Domain And EGF Like Domain Containing 1; SRRM3, Serine/Arginine Repetitive Matrix 3; AOC3, Amine Oxidase Copper Containing 3; KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1; LSM7, U6 snRNA-associated Sm-like protein 7.