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. 2019 Nov 26;10:2707. doi: 10.3389/fimmu.2019.02707

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Copyright © 2019 Jiang, Wang, Liang, Nie, Chang, Xue, Li and Min.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Confocal microscopy images of cortex, hippocampus, and hypothalamus of mouse brain after intranasal injection with Cy7.5 alone or Cy7.5-MMI-0100. (B) Ex vivo NIR fluorescence imaging and fluorescence intensity of perfused mouse brains 2 h after intranasal injection of the Cy7.5-MMI-0100, Cy7.5 alone, and saline as controls. All data are expressed as mean ± SEM and were analyzed by one-way ANOVA followed by Dunnett's post-hoc test. n = 4/group. ***p < 0.001 compared with Cy7.5 vs. Cy7.5-MMI-0100. Vertical lines represent mean ± SEM.