Table 3.
Costs of the single vial, number of vials and relative cost for the preparation of a single dose of medication (IV Station® and manual).
| IV Station | Manual | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acyclovir | Ampicillin | Amoxicillin + Clavulanic Acid | Ampicillin + Sulbactam | Dobutamine | Fluconazole | Metronidazole | Paracetamol | Teicoplanin | Vancomycin | Acyclovir | Ampicillin | Amoxicillin + Clavulanic Acid | Ampicillin + Sulbactam | Dobutamine | Fluconazole | Metronidazole | Paracetamol | Teicoplanin | Vancomycin | |
| Single vial cost (€) | 7.70 | 4.08 | 2,42 | 6.80 | 4.69 | 0.50 | 0.29 | 0.60 | 41.60 | 1.04 | 7.70 | 4.08 | 2.42 | 6.80 | 4.69 | 0.50 | 0.29 | 0.60 | 41.60 | 1.04 |
| Number of vials (n) | 2 | 5 | 2 | 5 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Total cost of the drug (€) | 15.40 | 20.40 | 4.84 | 34.00 | 4.69 | 0.50 | 0.29 | 0.60 | 83.20 | 1.04 | 7.70 | 4.08 | 2.42 | 6.80 | 4.69 | 0.50 | 0.29 | 0.60 | 41.60 | 1.04 |
| Vial drug content (mg) | 250 | 1000 | 1200 | 1000 | 250 | 100 | 500 | 1000 | 200 | 500 | 250 | 1000 | 1200 | 1000 | 250 | 100 | 500 | 1000 | 200 | 500 |
| Vial drug volume (mL) | 0 | 0 | 0 | 0 | 20 | 50 | 100 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | 20 | 50 | 100 | 100 | 0 | 0 |
| Mean drug doses pro Kg (mg/Kg/dosis) | 20 | 50 | 50 | 50 | 5 | 3 | 7.5 | 10 | 8 | 10 | 20 | 50 | 50 | 50 | 5 | 3 | 7.5 | 10 | 8 | 10 |
| Volume of Drug Reconstitution (mL) | 5 | 5 | 5 | 5 | 0 | 0 | 0 | 0 | 5 | 5 | 10 | 20 | 20 | 20 | 30 | 0 | 0 | 0 | 20 | 100 |
| Final dilution volume (mL) | 108 | 120 | 108 | 120 | 109 | 50 | 100 | 100 | 108 | 104 | 50 | 20 | 20 | 20 | 50 | 50 | 100 | 100 | 20 | 100 |
| Final drug concentration (mg/ml) | 3.7037 | 33.3333 | 14.8148 | 33.3333 | 1.0321 | 2 | 5 | 10 | 2.9630 | 3.8462 | 5 | 50 | 60 | 50 | 5 | 2 | 5 | 10 | 10 | 5 |
| Administration volume (mL) | 5.4 | 1.5 | 3,4 | 1.5 | 7.0 | 1.5 | 1.5 | 1.0 | 2.7 | 2.6 | 4.0 | 1.0 | 1.0 | 1.0 | 1.5 | 1.5 | 1.0 | 0.8 | 2.0 | |
| Drug stability (h) | 24 | 12 | 1 | 12 | 48 | 48 | 48 | 48 | 48 | 48 | ns | ns | ns | ns | ns | ns | ns | ns | ns | ns |
| Number of possible administrations (n) | 20 | 80 | 32 | 80 | 16 | 33 | 67 | 100 | 40 | 40 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Num. admin. amortize costs (n) | 2 | 3 | 2 | 4 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
h, hours; mg, milligrams; mL, milliliters; n, numbers; ns, not store. Doses of amoxicillin + clavulanate and ampicillin + sulbactam are referred to as amoxicillin and ampicillin alone.