Table 1.
Bone marrow cell subsets.
| SIRT2/3+/+ (n = 4) | SIRT2−/− (n = 4) | SIRT3−/− (n = 4) | SIRT2/3−/− (n = 4) | |
|---|---|---|---|---|
| B220+ B cells | 13.2 ± 1.9 | 15.5 ± 3.8 | 17.2 ± 0.7 | 17.4 ± 1.3 |
| CD3+ T cells | 4.6 ± 0.9 | 3.5 ± 1.1 | 5.2 ± 1.1 | 3.6 ± 1.1 |
| CD11c+ DCs | 3.8 ± 0.3 | 3.3 ± 0.2 | 3.8 ± 0.3 | 3.6 ± 0.2 |
| pCDs | 63.6 ± 2.2 | 64.3 ± 2.6 | 62.2 ± 0.9 | 67.4 ± 4.0 |
| cDCs | 33.4 ± 2.0 | 32.8 ± 2.7 | 34.2 ± 0.9 | 29.9 ± 3.7 |
| cDC1 (CD11b−) | 51.0 ± 2.9 | 49.7 ± 8.2 | 48.0 ± 4.6 | 52.7 ± 3.6 |
| cDC2 (CD11b+) | 45.8 ± 2.9 | 47.4 ± 8.5 | 48.0 ± 4.6 | 44.3 ± 3.4 |
| Ly6G+ Ly6C− granulocytes | 48.1 ± 3.3 | 48.2 ± 4.2 | 44.3 ± 0.9 | 44.9 ± 1.0 |
| Ly6G− Ly6C+ monocytes | 15.4 ± 0.8 | 15.3 ± 2.4 | 15.0 ± 0.7 | 15.3 ± 0.7 |
| Ly6Clow alternative monocytes | 44.9 ± 0.9 | 40.4 ± 2.0 | 38.9 ± 2.2 | 40.7 ± 2.8 |
| Ly6Chigh classical monocytes | 48.0 ± 0.5 | 51.8 ± 1.7 | 52.2 ± 1.8 | 50.1 ± 2.9 |
Data are mean ± SD of four mice per group and are expressed as the percentage of CD45+ cells (B220+, CD3+, CD11c+, Ly6G+Ly6C−, Ly6G−Ly6C+) or the percentage of parental cells. The number of CD45+ cells per leg was 14.4 ± 2.5, 14.9 ± 2.3, 12.0 ± 3.1, and 12.6 ± 4.2 × 106 cells for SIRT2/3+/+, SIRT2−/−, SIRT3−/−, and SIRT2/3−/− mice. Gray background: P < 0.05 vs. SIRT2/3+/+ mice.