Table 2.
Thymic cell subsets.
| SIRT2/3+/+ (n = 4) | SIRT2−/− (n = 4) | SIRT3−/− (n = 4) | SIRT2/3−/− (n = 4) | |
|---|---|---|---|---|
| CD4− CD8− | 3.3 ± 0.2 | 3.3 ± 0.3 | 3.9 ± 0.6 | 4.1 ± 0.4 |
| DN1 (CD25− CD44+) | 20.2 ± 3.2 | 21.1 ± 0.6 | 21.9 ± 6.8 | 21.5 ± 1.7 |
| DN2 (CD25+ CD44+) | 21.0 ± 2.4 | 19.8 ± 2.3 | 20.9 ± 1.7 | 21.2 ± 2.1 |
| DN3 (CD25+ CD44−) | 35.7 ± 2.5 | 35.3 ± 1.2 | 32.6 ± 2.0 | 32.0 ± 1.1 |
| DN4 (CD25− CD44−) | 23.1 ± 1.5 | 23.8 ± 2.7 | 24.6 ± 3.6 | 25.3 ± 1.9 |
| CD4+ CD8+ | 84.6 ± 1.2 | 82.4 ± 0.7 | 80.9 ± 3.1 | 81.1 ± 0.2 |
| CD4+ | 6.8 ± 0.7 | 8.1 ± 0.4 | 8.7 ± 1.9 | 8.2 ± 0.5 |
| CD8+ | 1.6 ± 0.3 | 2.3 ± 0.2 | 2.1 ± 0.7 | 2.0 ± 0.4 |
Data are mean ± SD of four mice per group expressed as percentage of total thymocytes (CD4− CD8−, CD4+ CD8+, CD4+, CD8+) or the percentage of CD4− CD8− cells (CD25− CD44+, CD25+ CD44+, CD25+ CD44−, CD25− CD44−). Thymus weights were 71.3 ± 8.6, 107.0 ± 20.9, 90.5 ± 15.6, and 89.5 ± 5.3 mg for SIRT2/3+/+, SIRT2−/−, SIRT3−/−, and SIRT2/3−/− mice. Gray background: P < 0.05 vs. SIRT2/3+/+ mice.