Table 3.
Overlap of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways significantly activated (p-value < 0.05) in vivo and in vitro, 24 h after high-dose thioacetamide/thioacetamide-S-oxide exposure.
| KEGG pathway (p-value < 0.05, bold p-value < 0.01) |
In vivo-In vitro overlap | Function | |
|---|---|---|---|
| Liver | Kidney | ||
| Limonene and pinene degradation | √ | Metabolism | |
| PPAR signaling pathway | √ | Endocrine system | |
| Ascorbate and aldarate metabolism | √ | Metabolism | |
| Butanoate metabolism | √ | Metabolism | |
| Tyrosine metabolism | √ | Metabolism | |
| Cardiac muscle contractiona | √ | √ | Circulatory system |
| Antigen processing and presentation | √ | √ | Immune system |
| Oxidative phosphorylation | √ | √ | Metabolism |
| Glutathione metabolism | √ | √ | Metabolism |
| Linoleic acid metabolism | √ | √ | Metabolism |
| Metabolism of xenobiotics by cytochrome P450 | √ | √ | Metabolism |
| Drug metabolism cytochrome P450 | √ | √ | Metabolism |
| Pentose and glucuronate interconversions | √ | Metabolism | |
| Arginine and proline metabolism | √ | Metabolism | |
| Taurine and hypotaurine metabolism | √ | Metabolism | |
| Selenoamino acid metabolism | √ | Metabolism | |
| Porphyrin and chlorophyll metabolism | √ | Metabolism | |
| Nitrogen metabolism | √ | Metabolism | |
aBold text indicates significantly activated pathway with a p-value < 0.01.