Table 4.
Activation of liver injury modules in vivo from rat liver tissue after exposure to thioacetamide.
| Low dose | High dose | ||||||
|---|---|---|---|---|---|---|---|
| 8 h | 24 h | 8 h | 24 h | ||||
| Module | z-score | Module | z-score | Module | z-score | Module | z-score |
| Oval cell proliferationa | 8.5 | Anisonucleosis | 14.7 | Cellular infiltration | 6.8 | Cellular infiltration | 14.9 |
| Single cell necrosis | 6.7 | Cellular infiltration | 14.2 | Single cell necrosis | 6.0 | Fibrosis | 12.0 |
| Nuclear alteration | 5.6 | Fibrosis | 11.1 | Oval cell proliferation | 4.6 | Cellular foci | 10.0 |
| Cellular infiltration | 5.2 | Oval cell proliferation | 9.6 | Cellular foci | 3.8 | Anisonucleosis | 9.1 |
| Anisonucleosis | 3.4 | Cellular foci | 9.0 | Anisonucleosis | 3.7 | Oval cell proliferation | 8.0 |
| Bile duct proliferation | 3.2 | Single cell necrosis | 4.6 | Fibrosis | 3.1 | Single cell necrosis | 6.5 |
| Cellular foci | 1.8 | Nuclear alteration | 4.1 | Bile duct proliferation | 3.1 | Nuclear alteration | 5.0 |
| Hematopoiesis | 1.5 | Bile duct proliferation | 3.6 | Nuclear alteration | 2.4 | Bile duct proliferation | 4.8 |
| Fibrosis | 1.1 | Hematopoiesis | 2.9 | Hematopoiesis | 2.3 | Hematopoiesis | 3.4 |
| Cytoplasmic alteration | 0.8 | Granular degeneration | 1.4 | Cytoplasmic alteration | 1.1 | Cytoplasmic alteration | -0.5 |
| Granular degeneration | -0.8 | Cytoplasmic alteration | 0.2 | Granular degeneration | 0.2 | Granular degeneration | -0.9 |
aBold text indicates significantly activated module (p-value < 0.01).