Table 5.
Activation of kidney injury modules in vivo from rat kidney tissue after exposure to thioacetamide.
| Low dose | High dose | ||||||
|---|---|---|---|---|---|---|---|
| 8 h | 24 h | 8 h | 24 h | ||||
| Module | z-score | Module | z-score | Module | z-score | Module | z-score |
| Necrosisa | 5.2 | Necrosis | 2.6 | Necrosis | 7.3 | Necrosis | 15.3 |
| Dilatation | 0.6 | Dilatation | 1.6 | Cellular infiltration | 1.7 | Cellular infiltration | 11.2 |
| Degeneration | 0.2 | Degeneration | 0.9 | Degeneration | 1.5 | Degeneration | 11.2 |
| Cellular infiltration | -1.8 | Cellular infiltration | 0.7 | Hyaline cast | 0.6 | Hyaline cast | 6.4 |
| Hyaline cast | -2.0 | Hyaline cast | -0.5 | Hypertrophy | 0.2 | Dilatation | 6.4 |
| Hypertrophy | -2.1 | Hypertrophy | -1.0 | Intracytoplasmic inclusion body | -0.3 | Fibrosis | 1.5 |
| Intracytoplasmic inclusion body | -2.4 | Intracytoplasmic inclusion body | -2.7 | Dilatation | -0.7 | Intracytoplasmic inclusion body | -0.1 |
| Fibrosis | -3.7 | Fibrosis | -3.0 | Fibrosis | -0.9 | Hypertrophy | -1.7 |
aBold text indicates significantly activated module (p-value < 0.01).