Table 6.
Activation of liver injury modules in vitro from rat hepatocytes after exposure to the thioacetamide metabolite, thioacetamide-S-oxide.
| Low dose | High dose | ||||||
|---|---|---|---|---|---|---|---|
| 9 h | 24 h | 9 h | 24 h | ||||
| Module | z-score | Module | z-score | Module | z-score | Module | z-score |
| Hematopoiesis | -0.4 | Fibrosisa | 6.4 | Hematopoiesis | 1.0 | Anisonucleosis | 6.9 |
| Anisonucleosis | -1.3 | Anisonucleosis | 5.6 | Anisonucleosis | 0.3 | Fibrosis | 6.5 |
| Granular degeneration | -1.5 | Cellular foci | 5.2 | Single cell necrosis | 0.1 | Cellular foci | 6.1 |
| Fibrosis | -1.8 | Bile duct proliferation | 3.4 | Granular degeneration | -0.7 | Bile duct proliferation | 3.7 |
| Bile duct proliferation | -1.8 | Cellular infiltration | 3.3 | Fibrosis | -0.9 | Cellular infiltration | 3.6 |
| Cytoplasmic alteration | -2.2 | Single cell necrosis | 2.4 | Nuclear alteration | -0.9 | Oval cell proliferation | 1.2 |
| Cellular infiltration | -2.2 | Oval cell proliferation | 2.2 | Cellular foci | -1.1 | Single cell necrosis | 1.0 |
| Cellular foci | -2.3 | Nuclear alteration | 0.2 | Oval cell proliferation | -1.4 | Nuclear alteration | 0.1 |
| Single cell necrosis | -2.4 | Hematopoiesis | 0.0 | Bile duct proliferation | -2.1 | Hematopoiesis | -0.2 |
| Oval cell proliferation | -3.8 | Granular degeneration | -1.6 | Cellular infiltration | -2.1 | Cytoplasmic alteration | -1.6 |
| Nuclear alteration | -4.5 | Cytoplasmic alteration | -1.6 | Cytoplasmic alteration | -2.2 | Granular degeneration | -1.9 |
aBold text indicates significantly activated module (p-value < 0.01).