Table 7.

Activation of kidney injury modules in vitro from renal tube epithelial cells after exposure to thioacetamide metabolite, thiacetamide-S-oxide.

Low dose				High dose
9 h		24 h		9 h		24 h
Module	z-score	Module	z-score	Module	z-score	Module	z-score
Fibrosisa	3.3	Hypertrophy	1.6	Hypertrophy	1.8	Cellular infiltration	1.9
Hypertrophy	1.7	Intracytoplasmic inclusion body	-0.2	Necrosis	1.3	Fibrosis	1.1
Cellular infiltration	1.3	Fibrosis	-0.3	Degeneration	1.2	Intracytoplasmic inclusion body	1.1
Degeneration	1.0	Cellular infiltration	-1.1	Dilatation	1.1	Hypertrophy	1.0
Dilatation	0.8	Dilatation	-1.1	Fibrosis	1.1	Necrosis	0.5
Intracytoplasmic inclusion body	0.0	Necrosis	-1.2	Cellular infiltration	0.4	Dilatation	0.1
Hyaline cast	-0.2	Hyaline cast	-1.3	Intracytoplasmic inclusion body	0.2	Hyaline cast	-0.5
Necrosis	-0.6	Degeneration	-1.8	Hyaline cast	-0.6	Degeneration	-1.2

^aBold text indicates significantly activated module (p-value < 0.01).