Figure 3.

Influences of ovariectomy (OVX) and anisodamine (Ani)/E₂ treatment on serum K⁺ and E₂ in mice with crush syndrome (CS). Ani (28 mg/kg, i.p.) or E₂ (100 mg/kg, i.p.) was administrated at 30 min before decompression in mice with CS 2 weeks after OVX surgery or its sham operation. Blood samples were collected at 6 h after decompression. OVX increases serum K⁺ level after decompression. Both Ani and E₂ eliminated OVX-induced difference in serum K⁺ and decreased serum K⁺ in CS models (A). OVX decreased serum E₂ level, and E₂ treatment narrowed such difference. Both Ani and E₂ increased serum E₂ in CS models received OVX surgery (B). N = 6 per group. *P < 0.05, **P < 0.01 vs. sham. Sham, sham operation for OVX surgery.