Figure 4.

Anisodamine (Ani) and E₂ decreases mortality in mice with crush syndrome (CS). Ani (28 mg/kg, i.p.) or E₂ (100 mg/kg, i.p.) was administrated at 30 min before decompression in mice with CS 2 weeks after ovariectomy (OVX) surgery or its sham operation. Both Ani and E₂ prolonged survival time in mice with CS received OVX surgery (B) or its sham operation (A). N = 20 per group. ^* P < 0.05, ^** P < 0.01 vs. CS model.