Figure 5.

Anisodamine (Ani) increases insulin sensitivity in male mice with crush syndrome (CS). Ani (28 mg/kg, i.p.) was administrated at 30 min before decompression in mice with CS, and methyllycaconitine (MLA) (10 mg/kg, i.p.) was given 30 min earlier. Blood samples were collected at 6 h after decompression. Ani reduced serum insulin level (A) and homeostasis model assessment of insulin resistance index (C), elevated quantitative insulin sensitivity check index (D) after decompression, but had no significant effect on serum glucose level (B). MLA significantly counteracted such effects of Ani. N = 6 per group. **P < 0.01 vs. CS model. ^## P < 0.01 vs. Ani.