Figure 7.

Influences of ovariectomy (OVX) and Anisodamine (Ani)/E₂ treatment on insulin sensitivity in mice with crush syndrome (CS). Ani (28 mg/kg, i.p.) or E₂ (100 mg/kg, i.p.) was administrated at 30 min before decompression in mice with CS 2 weeks after OVX surgery or its sham operation. Blood samples were collected at 6 h after decompression. OVX elevated serum insulin level (A) and homeostasis model assessment of insulin resistance index (C), reduced quantitative insulin sensitivity check index (D) after decompression, but had no significant effect on serum glucose level (B). Both Ani and E₂ eliminated OVX-induced difference in insulin sensitivity and increased insulin sensitivity in CS models. N = 6 per group. *P < 0.05 vs. Sham, sham operation for OVX surgery.