Figure 3.
Treatment with bifunctional vector enhances the activation of NK and CD8+ T cells in vivo. The percentages and activation of tumor-infiltrating leukocytes in C57BL/6 mice was determined via flow cytometric analysis. (A) CD8+ T cells. (B) NK cells. (C) CD4+ T cells. (D) Treg cells. (E) M-MDSCs and PMN-MDSCs. Data are representative of three independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. control group. NK, natural killer; Treg, regulatory T cell; M-MDSC, monocytic myeloid-derived suppressor cell; PMN, polymorphonuclear.