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. 2019 Nov 26;10:2721. doi: 10.3389/fimmu.2019.02721

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Copyright © 2019 Liu, Hu, Guo, Yu, Shao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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pDCs are necessary for the activation of NK cells and CD8⁺ T cells in vivo. The percentages and activation of CD8⁺ T cells (A), NK cells (B), and Treg cells (C) in tumor tissues after pDC depletion were determined by flow cytometric analysis. (D) Serum levels of IFN-α and IFN-β were detected by ELISA after pDC depletion. Data are representative of three independent experiments. **P < 0.01 or *P < 0.05 vs. control group. pDCs, plasmacytoid dendritic cells; NK, natural killer; Treg, regulatory T cell; IFN, interferon.