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Benchmarking of LCA against Seurat and SC3 on simulated datasets. (A) Clustering accuracy by LCA, Seurat, and SC3 was compared using NMI on 1000 simulated cells by Splatter: the probability of differential expression ranges from 0.05 to 0.2, and the probability of minor group ranges from 0.01 to 0.5. Each combination of simulation parameters contained 100 randomly generated samples. (B) Clustering accuracy by LCA, Seurat, and SC3 on 4000 simulated cells.
