Figure 5.

Reanalysis of melanoma cellular data (27) with LCA. We applied LCA to 1169 malignant cells from eight tumors and to 2588 stromal cells. LCA identified 18 clusters with a clear biological interpretation. LCA further revealed subtle diversity among the infiltrating T cells. (A) t-SNE (t-Distributed stochastic neighbor embedding) plot of the clustering results for malignant cells, contrasting the LCA results and original results. (B) t-SNE plot of the clustering results for stromal cells, contrasting the LCA results and original results. (C) Enrichment of gene markers in T-cell clusters.