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. 2019 Nov 26;10:2749. doi: 10.3389/fimmu.2019.02749

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Copyright © 2019 Agallou, Athanasiou, Kammona, Tastsoglou, Hatzigeorgiou, Kiparissides and Karagouni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression profile is similar among vaccinated (p8-CPA_160−189) and non-vaccinated (PBS) mice at late chronic VL phase. (A) Venn diagrams of up- and down-regulated DEGs during infection in vaccinated and non-vaccinated mouse groups. (B) Cumulative Distribution Functions (CDFs) of immunity-related genes across contrasts. CDFs in gray where obtained by random sampling of equal numbers from each contrast among all genes. Distribution shifts were assessed using Wilcoxon rank-sum tests. (C) Top 10 Gene Ontology Biological Processes (GO-BP) analysis and (D) KEGG pathway analysis for the common up-regulated DEGs among non-vaccinated mice and vaccinated mice groups.