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. 2019 Nov 26;10:2749. doi: 10.3389/fimmu.2019.02749

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Copyright © 2019 Agallou, Athanasiou, Kammona, Tastsoglou, Hatzigeorgiou, Kiparissides and Karagouni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STRING analysis of the DEGs that were significantly up-regulated (p < 0.05, fold change > 2) in both vaccinated (p8-CPA_160−189) and non-vaccinated (PBS) mice at late chronic phase of VL. STRING analysis achieved a PPI network of 271 nodes and 729 edges, with PPI enrichment p < 1.0e⁻¹⁶. Red shows genes involved in “immune system” term, blue shows genes involved in “innate immune responses” term and green show genes involved in “neutrophil infiltration” term. Lines in different color represent 7 types of evidence used in predicting associations. Red line: fusion evidence; green line: neighborhood evidence; blue line: co-occurrence evidence; purple line: experimental evidence; yellow line: text mining evidence; light blue line: database evidence and black line: co-expression evidence.