Table 1.
Physicochemical properties of the synthesized p8-PLGA nanoparticlesa.
| Formulation | Average size (nm) | Zeta potential (mV) | Antigen loading (μg/ml) | Antigen EEb(%) | p8 loading (μg/ml) | p8 CEc (%) |
|---|---|---|---|---|---|---|
| PLGA | 312.8 ± 3.8 | −19.1 ± 5.7 | - | - | - | - |
| p8-PLGA | 417.0 ± 25.1 | −4.9 ± 4.8 | - | - | 10 ± 10 | 63.6 ± 1.5 |
| p8-PLGA-CPA160−189 | 428.4 ± 35.4 | −5.7 ± 3.9 | 15 ± 3 | 67.5 ± 12.1 | 9 ± 0.2 | 61.9 ± 0.1 |
a
Results are presented as mean ± S.D. (n = 3), where applicable.
b
EE: encapsulation efficiency.
c
CE: conjugation efficiency.